|
KMID : 1161520110150020107
|
|
Animal Cells and Systems
2011 Volume.15 No. 2 p.107 ~ p.114
|
|
|
Toxicoproteomic identification of TiO2 nanoparticle-induced protein expression changes in mouse brain
|
|
Jeon Yu-Mi
Park Seul-Ki
Lee Mi-Young
|
|
|
Abstract
|
|
|
|
A proteomic analysis of the proteins in mouse brain that were differentially expressed in response to TiO2 nanoparticles was conducted to better understand the molecular mechanism of TiO2 nanoparticle-induced brain toxicity at the protein level. A total of 990 proteins from mouse brain were resolved by two-dimensional gel electrophoresis. A comparative proteomic analysis revealed that the expression levels of 11 proteins were changed by more than 2-fold in response to TiO2 nanoparticles: eight proteins were upregulated and three were downregulated by TiO2 nanoparticles. In addition, the activities of several antioxidative enzymes and acetylcholine esterase were reduced in TiO2 nanoparticle-exposed mouse brain. The protein profile alterations seem to be due to an indirect effect of TiO2 nanoparticles, because TiO2 nanoparticles were not detected in the brain in this investigation.
|
|
|
KEYWORD
|
|
|
proteomics, TiO2 nanoparticles, mouse, brain
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|